Effects of Urotensin-II and Somatostatin -25 on carbohydrate and lipid metabolism of frog Rana pipiens

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Muhammad Zafar, Muhammad Muzammil Malik, Iram Mushtaq, Zahra Batool, Samrah Masud, Sadia Bibi, Muhammad Hashir Latif Muhammad Sharjeel Noor, Muhammad Talal, Muhammad Taqadas Sajjad, Sajid Ali

Abstract

The study was conducted to find out the metabolic activity of lipid and carbohydrate which is involves the nerve impulse transmission, energy storage, hormone regulation and fat-soluble nutrient transportation in human bodies. Does dependent significant hypoglycaemia caused by Urotensin II and Somatostatin-25 were studied and observed increase in plasma free fatty acids which diminished with time and increased liver glycogen contents. Higher doses of Urotensin-II (5ng/g body weight for 6hr) and Somatostatin-25 (10 ng/g body weight for 6 hr) were more potent to increase plasma protein and plasma total lipids, whereas weaker doses of both did not show any type of effect. These results show that partial homology and partial analogy of Urotensin-II and Somatostatin-25 contribute towards similar type of effect on carbohydrate and lipid metabolism in frog Rama pipiens.  Based on the current study, the more specific work can be done in context of the metabolic syndrome, in diabetes and in cardiovascular disease.


Keywords: Blood Plasma; Carbohydrate; Corticosteroids; Freefattyacid; Lipid; Metabolism; Palmaglucasse; Somatostatin-25; Urotensin-II


http://dx.doi.org/10.19045/bspab.2024.130034

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