In Vitro Biological activity of Traditionally Used Wild Medicinal Plants of Solanaceae from Sibi District Balochistan Pakistan
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Abstract
Solanaceae plants have been identified as one of the main resource of traditional medicines and rich in bioactive compounds mainly in high valued Wild taxa. The present study is aimed to investigate the presence of phytochemicals and in-vitro anti diabetic and anti-inflammatory activity of six wild taxa belonging to three genera of Solanaceae frequently used by the indigenous communities of Sibi District, Balochistan Pakistan. Plant samples were collected during various field surveys in town and suburbs. Different plant parts were subjected to determine the phytochemicals, Anti-diabetic activity by using in vitro α-amylase enzyme inhibition method and anti-inflammatory activity by protein denaturation method. Results exhibited the presence of total phenol, flavonoid content, alkaloids, tannins and saponins in different parts of selected plants. Seeds of Withania somnifera exhibited the highest anti-inflammatory activity (84.5±0.5% Inhibition) followed by Seeds of WC (81.5±2%). Whereas, the highest anti-diabetic activity was depicted in seeds of W. coagulans (81. 5±0.5% Inh.) followed by followed by Seeds of WC (81.5±2%). Findings of the study revealed that a significant amount of biologically active components are present in selected plants. The outcome of the study will augment the better understanding about the potential use of these plants in nutraceutical and pharmaceutical formulations of selected plants. These plants can be utilized for new phytopharmaceutical and nutraceutical preparations. Conservation through cultivation of these significant medicinal taxa of the family is highly recommended.
Keyword: Anti-oxidant; Balochistan; Bioactivity; Phytochemicals; Sibi; Solanaceae