72. Profiling and characterization of chemical and pathogenic cumulative stress responding genes in mouse liver
Abstract
The present study was done for the profiling and characterization of cumulative stress responding genes in mouse (Mus musculus) liver. The mouse liver responses to chemical and pathogenic stresses at transcriptome level provide an understanding for the profiling of stress responding genes. The cumulative chemical and pathogenic stress genes responding to three or more than three stress series will be a good source for genetic engineering at chemical and pathogenic stress resistance mechanism in liver. In mouse various studies have been made for the analysis of gene expression under various chemical and pathogenic stress conditions using DNA microarray technology. These available microarray data under chemical and pathogenic stresses like; aromatic compounds, perflurooctonic sulphate, arsenic and Helicobacter hepiticus were analyzed by applying the bioinformatics tools. Total 363 cumulative chemical and pathogenic stress responding genes were profiled and characterized at different stages after the analysis of 45101 genes. The chemical and pathogenic stress responding genes were characterized on the basis of their functions.
Keywords: Gene expression; Gene ontology; DNA microarray; Chemical stress; Pathogenic stress
