01. Apoptosis: a therapeutic strategy in eosinophilia
Abstract
Eosinophils have crucial role in allergic inflammation and asthma. Prolong survival and pathological accumulation at the site of inflammation exclusively related to destructive activity of these pathogenic granulocytes by releasing tissue toxic and inflammatory granule proteins. Any deficiency in eosinophil apoptosis may put in to condition of eosinophilia. Thus, removal of eosinophils by inducing apoptosis has been proposed as potential anti inflammatory strategy in eosinophilia. Apoptosis proves to be beneficial for development of future airway drugs. For therapeutic instances, many reviews illustrate the importance of glucocorticoids as potent anti-inflammatory agent and known to induce apoptosis in eosinophils. Apart from glucocorticoids, theophylline and histamine are well studied apoptosis inducing agents in eosinophil related inflammation. This review elaborates the anti-inflammatory characters of apoptosis in asthma and allergic inflammation.
Keywords. Apoptosis, Eosinophilia, inflamation
