CNS depressant and analgesic effects of Withania coagulans (Stocks) dunal fruits collected from Khuzdar district of Balochistan, Pakistan

Abstract

Withania coagulans (Stocks) Dunal (Solanaceae) have been reported with various uses such as emetic, sedative, diuretic, alterative in chronic liver disorders, dyspepsia, intestinal infections and colic pain. This study aims to investigate the central nervous system (CNS) depressant, anxiolytic and analgesic effects of methanolic extract of W. coagulans. CNS depressant activity of crude methanolic extract of W. coagulans fruits was evaluated using standard animal behavioural models such as open field, cage crossing, rearing and traction test. Anxiolytic activity was evaluated through forced swimming test whereas analgesic activity was carried out via acetic acid induced writhing and formalin test in mice. The extract (100 and 250mg/kg) showed a dose-dependent suppression of motor and exploratory (Neuropharmacological) activity for mice in open field, cage crossing, rearing and traction test. Significant writhing effect i.e. decrease in number of writhes as well as analgesic effects were observed (P<0.05).The findings of current research work supports the CNS sedative and analgesic potential of W. coagulans. 

Keywords: Analgesic; Writhing test; Balochistan; Khuzdar; Withania coagulans

http://dx.doi.org/10.19045/bspab.2017.60066